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Noun-noun compounds work in lots of ways.
(A few other known compounds work in a similar way, including vancomycin).
In a paper published online Sunday in Nature Medicine, researchers from Eli Lilly and Co. in Indianapolis, Indiana, have shown that these compounds work in humans as well.
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I especially like the fact that both compounds work only in the gut (although we've had disappointments in that neighborhood before), eliminating or much reducing the likelihood of systemic side effects.
They will take potential drugs discovered at NIH and at universities and tweak their chemistry so the compounds work well in humans without causing toxic side effects—a slow, hard process.
"The compounding works in reverse," Mr. Felske said.
It will take five years of clinical trials to prove that the compound works in humans, he says.
By showing for the first time that the compound works in animals, the results bring human studies a step closer.
What's more, the new compound works in such a way that it's unlikely to fall prey to the problem of antibiotic resistance.
To see if the compound worked in live animals, a veterinary surgeon collaborating with Messersmith's team made a 2.5-centimeter incision in the carotid artery of a dog and placed four stitches along the length of that incision to hold it in place.
It's unclear whether these odor compounds work the same way in the body as they do in the nose, Schieberle said, but he hopes to find out.
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CEO of Professional Science Editing for Scientists @ prosciediting.com