Sentence examples for compounds with significant from inspiring English sources
Compounds with significant pA2 values exhibited good anti-depressant-like activity as compared to the vehicle-treated group.
When control or AGU patient fibroblasts were treated with 10 mM compounds (Fig. 5A C), a substantial increase of AGA enzyme activity was observed with all three compounds, with significant data for T122K mutation.
The traditional Chinese medicine (TCM) is a complex system, which always consists of numerous compounds with significant difference in the content and physical and chemical properties.
The rich wealth of plant kingdom can represent a novel source of newer compounds with significant therapeutic activities.
Often, high-scoring pathways lead to activity cliffs, i.e. pairs of similar compounds with significant differences in potency, and scaffold transitions can be observed along the pathways.
In this case novel derivatives of tryptanthrin-like and BII-like compounds with significant antibacterial activity were created, with the halogenated derivatives being superior to the non-halogenated compounds both in activity spectrum and in vitro efficacy.
2,3-Dihydro-5-hydroxy-2-methylchromen-4-one (TL1-1) is a phenolic compound with significant anti-fungal and anti-cancer activities produced by Daldinia eschscholzii (D. eschscholzii).
This study shows that β-glucoside 2 was the only compound with significant antinociceptive activity at doses of 2 and 4 mg/kg, along with slightly higher affinity for μ1 receptor.
On the other hand, the acetamido-, methyl- or chloro- substitution at the same position (21– 23) fails to generate a compound with significant inhibitory activity.
The cyclohexyl amide 11 afforded a 10-fold increase in activity against Leishmania CRK3, but more importantly, diminished HsCDK2 activity, resulting in a compound with significant selectivity for Leishmania CRK3 CYC6, although we cannot explain the detailed reasons for this from our model.
Uncoated SiC corroded severely, forming various Na2O·SiO2 compounds with a significant weight gain.
