Your English writing platform
Discover LudwigExact(6)
The factors contributing to the reduced electrical resistivity in Cu3NMgx compounds with larger x values are discussed.
Characterization of the binding pocket by a grid-based surface calculation of the docking model revealed a large unfilled hydrophobic region near the central phenyl ring, suggesting that compounds with larger hydrophobic groups in this region would improve binding.
For lower molecular weight compounds, such as fluorene and DEP, inhalation is the main route of exposure; whereas, for compounds with larger log Koa values such as DEHP and DEHA, exposure to dust (dermal and ingestion) dominates.
This is by no means a highly quantitative relationship; for example, compounds with larger envelope violations can have smaller worst-fold affinity losses (AF-78 vs AF-69), particularly against a relatively small panel of mutants.
However, a significant improvement in activity against all resistant organisms (MIC, 2 to 8 μg/ml) was observed by simple methyl substitution of the aminomethyl side chain compound 6, and potent activity (MIC, 0.25 to 2 μg/ml) was observed for the dimethyl-substituted compound 7 and compounds with larger, single-alkyl substitutions, such as compounds 8 and 9.
When we compared the inhibitory activity of the leads to adenine (10) (Supporting Information Figure 15), which contains the native N6 primary amine but similarly lacks the ribose ring and phosphates, we found that the lead compounds with larger N6 modifications were unexpectedly more effective at inhibiting HK853.
Similar(54)
Compounds with large cation size mismatch (large rA/rB) are more susceptible to radiation damage and amorphize more easily than those with small mismatches.
The group is also pursuing new avenues in the design of multinuclear transition metal compounds with large spin and magnetic anisotropy, as well as mononuclear and multinuclear complexes of the 5f-elements.
Dissolution from the oil body was greatest for compounds with large effective solubilities (benzene) and with large degradation rates (toluene and o-xylene).
Polar compounds with large molecular weight have poor membrane permeability, liposomes can promote drugs to penetrate epidermis and remain or release at dermis.
We have carefully estimated ΔSM of the compounds with large thermal hysteresis from the Maxwell relation using the magnetization temperature curves.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com