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Compounds with increased selectivity for it may provide significant activity and fewer side effects.
The aim of study was to screen designed compounds and select new compounds with increased COX-2 selectivity.
The results are sufficiently encouraging to suggest that CASE systems should become general utility tools for chemists to accelerate the identification of compounds with increased probability of success.
By molecular design it ought to be possible to generate new cis-platinum compounds with increased selectivity and improved cellular behaviour.
Incorporation of an α-methyl substituent in the pendent benzyl ether side chain gave compounds with increased selectivity over the hERG channel.
The poor specificity and the high toxicity of some available molecules have made imperative the search for new strategies to improve the specificity and to pursue the discovery of novel compounds with increased bioactivity.
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The tendency for TNI is to increase (going over 200∘C for some compounds) with increasing l.
Further they found that there was an increase in the yield of extracted compounds with increasing extraction time.
The increased selectivity toward less substituted polycyclic aromatic compounds with increasing acidity is related to the relative rates of cyclization and alkylation reactions within the zeolite structure.
Anodic oxidation of a number of water soluble organic compounds with increasing molecular mass from 46 Da to 72,000 Da was systematically investigated in a cell with a boron-doped diamond (BDD) anode under total recycle batch galvanostatic operation conditions.
In particular, lower concentrations of choline-containing compounds with increasing BMI suggesting membrane or myelin alterations were observed in frontal WM.
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CEO of Professional Science Editing for Scientists @ prosciediting.com