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In the study target compounds were very potent inhibitors of AChE and BChE.
Determination of the selective indexes indicated that 50% of the active compounds were very toxic for HepG2 cells.
The EDX results showed that the chemical compositions for both compounds were very close to the designed compositions.
Also the remaining compounds were very active, although their MIC and PI were in general lower than those of their parent 2-methyl analogues.
The compounds were very potent towards all tested Gram positive microorganisms (MIC ranging from 0.03 to 6 μg/mL in most of the cases) and Gram negative Haemophilus influenzae (MIC 0.15 1.5 μg/mL), whereas no effectiveness was exhibited against Gram negative Escherichia coli and fungi up to the concentration of 100 μg/mL.
It was found that the compounds were very sensitive to the presence of an acid yielding metal-free phthalocyanines irreversibly.
Similar(46)
"Detecting these compounds is very difficult.
The reports on asymmetric multibranched compounds are very limited.
Binary compounds are very common in inorganic chemistry, and they exhibit little structural variety.
Although these carbon compounds are very old, they are not fossils.
Hypervalent compounds are very common and in general are no less stable than compounds that conform to the octet rule.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com