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The chemical structures of these compounds were shown in Fig. 1 13C-NMR ofourur compounds were shown in Table 1.

These compounds were shown to have high affinity for the 5-HT6 receptor.

These compounds were shown to inhibit the proliferation of U87MG cells in the low micromolar range.

The IC50 values of these compounds were shown in Table 2.

The resolved mass spectra of these three compounds were shown in (Additional file 4: Figure S1).

Abundant product ions of these three compounds were shown in Table 1.

The structures of the training set compounds were shown in Fig. 2.

These compounds were shown to inhibit recombinant human HDAC1 with IC50 values in the sub-micromolar range.

All three compounds were shown to induce apoptosis in both ALL cell lines using flow cytometry and Western blotting.

The standard calibration curves of all compounds were shown in Table 2 with satisfactory linearity (r > 0.9882).

After formation, the synthesized compounds were shown to be very stable with no degradation due to humidity.

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