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Although initial compounds were highly active in Itk, they were not selective.
These compounds were highly selective for inhibition of JAK3 over JAK2 and TYK.
These compounds were highly soluble in common organic solvents, such as chloroform, toluene and chlorobenzene.
Two compounds were highly potent against the HL60 cell line and represent promising lead compounds for future development.
Curcumin analogues weakly inhibited 11β-HSD2, and further analyses revealed that these compounds were highly selective, favoring 11β-HSD1.
Two compounds were highly effective against MCF-7, Bewo and HL-60 cells with IC50 values in 0.63 13.12 μM.
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Eleven of the compounds are highly carcinogenic.
Mercury and its compounds are highly toxic.
The element and its compounds are highly toxic.
Antimony and a number of its compounds are highly toxic.
These compounds are highly deterrent to ants and mammals.
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