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Many phenolic compounds were discovered and used long before chemists were able to determine their structures.
Years later, toxic and environmentally hazardous properties of these compounds were discovered.
Through the optimization of the piperazine amide 1, several potent compounds were discovered.
Compounds were discovered with broad antibacterial spectrum, including activity against Pseudomonas aeruginosa, Acinetobacter baumannii and Escherichia coli.
Utilizing electrospray ionization mass spectrometry (ESI-MS) to provide binding information about complexes of enzyme and small molecule ligands, two classes of lead compounds were discovered.
Through iterative rounds of drug design, synthesis and biological evaluation, several compounds were discovered to target AKR1C3 in a selective manner.
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Besides, some new biological activities of these compounds are discovered.
A family of 4-heteroaryl-2-amino-pyrimidine CDK2 inhibitor lead compounds was discovered with the new database-mining program LIDAEUS through in silico screening.
However, this article highlights some of the exciting possibilities that have emerged from the earliest investigations in this field with new topological families of compounds being discovered from relatively simple framework components, including unusual eight, seven and five-connected framework systems.
It has been intensively studied in soldiers with respect to its anatomy and chemistry, with numerous novel compounds being discovered within the tremendous richness of identified products.
This method relatively rapidly assesses large numbers of compounds, but it does not determine whether a compound can be made or not; instead, only active compounds are discovered.
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CEO of Professional Science Editing for Scientists @ prosciediting.com