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The compounds were conjugated to the model electrophile ethacrynic acid (EA) to resemble GS-EA, an efficient GST inhibitor.
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These compounds are conjugated with thiols through reactions mediated by GST.
This highly reactive compound is conjugated with GSH, producing a decrease in GSH levels in neurons that leads to neuronal death.
The carboxylic acid precursor of the pyrimido[5,4- b]indole compound was conjugated to the primary amine functionality on the core.
Classically, the cytotoxic compound is conjugated to the targeting mAb via nondirected chemical linkage, often resulting in an undefined stoichiometry of ADCs and heterogenic positioning of the cytotoxic payload in relation to the binding protein, which can directly affect its therapeutic efficacy (Ducry and Stump, 2010).
Antibodies were conjugated to COINs.
If we assume that the compounds observed are conjugated hydrocarbons, the mass spectra of the organics are consistent with organic compounds of up to 22 carbon atoms.
These compounds can be conjugated as such to macromolecules or incorporated into polymeric or liposomal formulations to promote the efficient cellular delivery of macromolecules.
Other compounds have been conjugated to TPP.
Various homing ligands, including aptamers, peptides, antibodies, and small-molecular-weight organic compounds, have been conjugated on the surface of gold nanoshells.
In this proof-of-principle study, we selected Dex as the model compound to be conjugated to the delivery system.
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