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Some of the compounds were able to inhibit the reaction.
The compounds were able to inhibit TNKS2 with greater potency than CDK9.
The electrochemical studies revealed that these compounds were able to bind Ca2+ ions.
These compounds were able to gelate water at 1.0 wt% of concentration independently of the pH.
All compounds were able to release NO at levels ranging from 0.16 to 44.23%.
Some of the new compounds were able to inhibit HBV activity in the low micromolar range.
All the compounds were able to inhibit FGFR3 kinase activity at a concentration of 50 μM.
Analogously, all the compounds were able to inhibit the self β-amyloid1-42 aggregation.
Several compounds were able to significantly reduce viral replication in infected cells.
Three compounds were able to synergise with antibiotics and reverse resistance in the resistant phenotype.
Cell imaging experiment clearly suggest that compounds were able to cross cell membrane and accumulate thus causing cytotoxicity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com