Sentence examples for compounds we determined from inspiring English sources

Among thousands of compounds, we determined that Ponatinib, a tyrosine-kinase inhibitor, represses BCLM-associated gene expression via the ERK/c-Jun signaling pathway and inhibits BCLM in mouse models.

To further explore the functional interrelationship among ATP and the identified IDE-activating compounds, we determined the degree of activation produced by different doses of Ia1 and Ia2 in the absence or presence of a partially activating concentration of ATP (0.1 mM).

To ascertain the biological effects of these compounds, we determined the coherence of biological functions predicted from transcriptional perturbations with those encoded in QTL associated with dose response variation to the compounds.

To investigate the role of different cellular effector systems in the T2-prolonging effect of repolarization-prolonging compounds, we determined the effect of 4AP in the absence and presence of tetrodotoxin (INa), tetracaine (INa), verapamil (ICa), thapsigargin (SERCA), SEA0400 (sodium calcium exchanger, NCX) or JTV519 (respectivelyctively.

To accurately establish the binding mode of this compound we determined a high-resolution crystal structure of 1 bound to the CDC25B.

In this study, we identified the main hydroxylated polychlorinated biphenyls (OH-PCBs) and other chlorinated phenolic compounds and we determined their relative concentrations in whole blood from 13 male and 17 female Inuit from northern Quebec, Canada, and from a pooled whole blood sample from southern Quebec.

For each compound found, we determined the proportion of lung cancer patients in whose exhaled breath the compound appears, separately for smokers, exsmokers and non-smokers, see Figure 1.

As a second estimate of the error rate of the gene-compound correlates, we determined a false discovery rate, as estimated by a q-value, for each correlate.

To check whether the four Poitou individuals that were identified as heterozygous for the deletion were compound heterozygotes, we determined the genotypes of the cohort at the c.245G > A SNP.

In addition to the platinum compounds, we also determined the DNA damage and cytotoxicity provoked by adriamycin and gemcitabine, two chemotherapeutics also used in the treatment of recurrent ovarian carcinomas.

To better understand the nature of the interaction of these compounds with WDR5, we determined the crystal structures of WDR5-0102 and WDR5-0103 in complex with WDR5 (PDB codes 3SMR and 3UR4 respectively; Supplementary Table S1).