To enhance the pharmacokinetic (PK) profile of this compound, we conducted chemical modifications into its N-5 side chain and conversion of the chemically modified compounds into their salts.
In parallel with the DESPS of each compound, we conducted DNA encoding ligation control experiments (DE+, also using bifunctional-HDNA resin) in which the complete unique encoding sequence of the compound was prepared by serial ligation of primer and appropriate encoding modules absent compound synthesis steps.
The limited screen of 11 compounds that we conducted here did not identify any Orco agonists, but more extensive screening is clearly warranted.
To assess the performance of the proposed testing procedure for compound covariate, we conducted simulation studies under various scenarios to study type I error rate and power.
Based on complementary antiangiogenic activity (Williams et al, 2003; Ebos et al, 2007) and an expected synergy between the two compounds (Wright 2010), we conducted a phase 1 evaluation of sunitinib and bortezomib in patients with refractory solid tumours (NCT00720148).
In order to identify the key genes underlying the production of aroma compounds in peach, we conducted an integrative analysis using in-house-developed transcriptomic and metabolomic data sets.
To assess the stability of the complexes of chemical compounds with C60 fullerene, we conducted the short-molecular dynamics (MD, 25 ps) using a Nosé-Poincaré-Anderson algorithm (NPA) [25, 26].
Given that Leavens et al. (2007) indicate a greater role for dermal absorption for the brominated compounds than for TCM, we conducted sensitivity analyses to examine the contribution of activities with heavy dermal exposures.
In experimentally defining the concentration threshold at which the selected phenolic compounds completely inhibit yeast growth, we conducted toxicity screening on the phenolic compounds.
To assess the stability of the complexes of chemical compound with C60 fullerene, we conducted the short molecular dynamics (MD, 100 ps) using Gromacs software tool [23] according to a Nosé-Poincaré-Anderson algorithm (NPA) [24, 25] based on OPLS-AA force field [26, 27].
