Exact(2)
Given that the epigenome can be modified with small chemical compounds, understanding its role should contribute to effective cancer-treatment strategies.
The assay may also find application in screening of antiviral compounds, understanding of pathogenesis as well as evaluation of vaccine.
Similar(58)
Both the sources of the building units composing organic molecules (C, H, O, and N) and possible reaction pathways leading to organic compounds are multiple; therefore, determining the origin of organic compounds and understanding their formation appears a real challenge.
The discovery of herbal anti-inflammatory compounds and understanding their mode of action would contribute to the development of new therapies against chronic inflammation and its associated disorders.
Acetyltransferase inhibitors may therefore be useful as tool compounds in understanding acetyltransferase functions and also have the potential to treat a variety of diseases (which will be described in section 6).
Examples include: go/no go decisions, dose and schedule selections, optimal trial designs and analysis, comparator differentiation, risk-benefit analysis, discovery target choices, hypothesis testing in in silico models, comparing drug candidate efficacy/safety profiles, predicting human doses, optimal combinations of compounds, and understanding the right patient population.
We therefore conducted a high-throughput screen with a larger chemical library and 4-methylumbelliferyl laurate (4-MU laurate), a fluorogenic substrate with improved signal-to-noise properties, to identify more potent scaffolds for PvdQ inhibition that can serve as tool compounds for understanding pyoverdine maturation and therapeutic leads for P. aeruginosa infection.
Based on reported data about the pharmacological properties of praeruptorins and semisynthetic derivatives of them, it is hopeful that in the near future more studies focus on the discovery of the new application and therapeutic uses of these bioactive compounds and understanding the specific mechanisms of them.
Since CEppt is comprised of several molecules, characterizing the active compound and understanding the mechanism of action will require further work.
While berberine chloride has proven to be a valuable tool compound in understanding the mechanism of action its development as a drug is hampered by its poor physicochemical properties.
In some studies aimed at understanding phenolic compounds, compounds having similar functional groups have been grouped together while representative compounds of each group were studied (Larsson et al. [2000]), presumably under the assumption that compounds having the same functional group are similar in their inhibitory activities.
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