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The antimutagenicity results were expressed as percent inhibition (the ability of the compounds to inhibit the action of the known mutagen).
To estimate IC50 for APE1 inhibition, the ability of the compounds to inhibit APE1 at a range of concentrations (10 n–100 μ) were evaluated in black 384-well plates.
The ability of these compounds to inhibit the enzyme was evaluated.
The ability of the compounds to inhibit tubulin polymerization is reported and compared to thiocolchicine.
The ability of these compounds to inhibit tubulin polymerization and cell growth in selected human cancer cell lines was evaluated.
The ability of our synthetic compounds to inhibit ovine COX-1 and COX-2 was determined using a colorimetric method.
We further examined the potency of these two compounds to inhibit neuronal sodium currents recorded from cultured hippocampal neurons.
IC50 values for all prepared compounds to inhibit COX-1, COX-2 and 5-LOX enzymes were determined in vitro.
Significant (P < 0.001) reduction in free acidity in all compounds except compound 3a indicated the ability of test compounds to inhibit secretion of hydrochloric acid.
In addition, the choice of counterion can have a dramatic effect on the ability of these compounds to inhibit ice recrystallization.
The ability of the compounds to inhibit the growth of the human erythroleukemic K562 cell line and inhibit the decatenation activity of DNA topoisomerase IIα was also measured.
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