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Maximum optical yield is obtained with tiny amounts of a suitable alkaloid; the ability of such compounds to induce optical activity depends both on its adsorption at the mercury and the nature of the substrate.
The highly potential compounds to induce apoptosis in HepG2 cells were analyzed by flow cytometry, and the apoptotic effects of compounds 8b and 13c were further evaluated using Annexin V-FITC/propidium iodide dual staining assay.
The potential of these compounds to induce toxicity in Vero cells was also investigated and the majority of them showed lower or no cytotoxicity at 10 μg/mL than amphotericin B, the gold standard in antifungal drug development.
We report substantially different levels of exon skipping induced in normal and dystrophic human myogenic cell lines and propose that animal models or artificial assay systems useful in initial studies may be of limited relevance in designing the most efficient compounds to induce targeted skipping of human dystrophin exons for therapeutic outcomes.
The ability of copper compounds to induce intracellular superoxide anions and single-strand DNA breaks was assessed with recombinant bioluminescent bacteria, E. coli K12::soxRSsodAlux and E. coli MC1061 (pDEWrecAlux), respectively [17].
Surprisingly, when we examined the ability of these compounds to induce cell proliferation, we observed that despite having different degrees of partial agonist activities on classical transcriptional responses (i.e., induction of prostate-specific antigen), these compounds were as efficacious as dihydrotestosterone in stimulating proliferation.
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Prediction of the propensity of a compound to induce Torsades de Pointes continues to be a formidable challenge to the pharmaceutical industry.
Taken together, our study proposes that designing selenium compound to induce intra cellular GPx level not only provides radioprotection but also inhibits radiotherapy associated inflammatory side effects.
These results indicate the capability of the purified compound to induce apoptosis in lung cancer (A549) cells.
Sildenafil, a specific inhibitor of phosphodiesterase 5 (PDE5), was the first compound to induce migraine-like headache in a human headache model without a concomitant artery dilatation.
Dimethylation of the methylene bridge carbon of BD to give 2,2-dimethyl-5-t-butyl-1,3-benzodioxole (DBD) blocks the formation of NADPH-reduced Type III metabolite-P-450 complexes in vitro, and diminishes but does not abolish the ability of the compound to induce P-450b.
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