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The ability of various pyrrolobenzodiazepine(PBD -containing cytotoxic comPBD -containingion as hypoxia-acytotoxicprodrugs was assessed.
The X-ray structural analysis for one derivative illustrates the inclusion of two benzene molecules within the cavity, showing in a first approximation the capability of the polymacrocyclic compounds to function as molecular receptors.
For these compounds to function as substrates, a substitution at both ortho positions might be vital.
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The relative dependence of the IC50 values on the concentration of ATP used in the assays suggests that these compounds appear to function as irreversible inhibitors of each kinase.
Photocatalytic titanium dioxide (TiO2) substrates have been shown to eliminate organic compounds and to function as disinfectants [5].
The reducing power of compounds seems to function as an inhibitor of chain reactions of free radicals by means of donation of electrons, since this activity is mediated by redox reactions [ 43].
The coating (NASA designation PS304) is a chrome-oxide based plasma sprayed coating with embedded silver and BaF2/CaF2 eutectic compound particles to function as solid lubricants.
Specifically, compound 12c was the strongest AChE inhibitor, being 20-fold more potent than galanthamine and twofold more potent than tacrine, and it also had ability to inhibit Aβ aggregation (close to the reference compound) and to function as a metal chelator.
Arguably the most advanced-stage example of a compound thought to function by blocking viral entry is SP-303 (also known as Virend), a proanthocyandin oligomer tested in phase 2 clinical trials as a topical treatment for anal and genital herpes.
The poor solubility and high plasma protein binding activity of these probes will need to be taken into consideration by researchers who use these compounds to investigate p97 function.
The enzymatic transglycosylation by dextransucrase from Leuconostoc mesenteroides has been previously used for the modification of various bioactive compounds to improve their function or physical stability (Moon et al. 2007a; Seo et al. 2009).
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