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Interspecies interactions of oral streptococci involve the production and excretion of antimicrobial compounds to compete successfully during colonization.
In order to test this hypothesis, we assessed the ability of these test compounds to compete for binding of the radiolabeled MPEP analogue [H]3-methoxy-5- pyridin-2-ylethynyl pyridine) ([H]3-methoxy-5- pyridin-2-ylethynyl pyridineraction witH]3-methoxy-5- pyridin-2-ylethynyl pyridine
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We next tested whether 6AP and GA share the same interaction site(s) on ribosomal constituents by determining the ability of each compound to compete for the binding of ribosomal proteins to the other compound.
At that time, the biphasic effect of some quinones (inhibitory at low concentration and inactive or even activating at high concentration) was explained by hypothesizing (i) that quinones formed aggregates at high concentrations and (ii) that these aggregates were either inactive or activating compounds able to compete with the monomeric-inhibiting quinone.
Chemical compounds, able to compete with Brn3 transcription factors, may provide the basis for Brn3a-specific inhibitors (Peixoto et al, 2008).
Inactivation of Shiga toxins by antitoxin antibodies [ 185] and by certain synthetic carbohydrate and peptide compounds designed to compete with the active site of the toxin for receptor sites on cell membranes has also been investigated [ 186– 186].
Although compound B1 and C1 could not produce the pi-stacking interaction with Phe731, both compounds which possessed the lower binding energy and higher dockscore than the two control compounds were believed to compete with the ATP molecule.
These compounds are able to compete with natural substrates, such as specific transcription factors, and alter gene expression.
Binding assays showed that some of these compounds were able to compete with labeled VEGF for interaction with the VEGFR-1 receptor.
These compounds are thought to compete with the C-terminal tail of the agonist.
The DOTA-conjugated compounds were allowed to compete against a fixed concentration of an NIR-emitting agent.
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