The difference in compound activities and the potential of compounds of this class for treating breast and ovarian cancer are discussed.
One of the most promising compounds in this class is Betulinic Acid (BetA), but its effect is limited by the poor solubility of the compound.
Compounds within this class promoted significant body weight reduction in mouse diet induced obesity studies.
Several compounds in this class have been synthesized starting from guanylthiourea and alkyl bromides.
Compounds in this class showed efficacy in human tumor xenograft models.
Compounds of this class can significantly reduce tumor growth in human tumor xenograft models.
where index j refers to one of the classes, N j – is a number of compounds in this class.
Representative compounds from this class show favorable pharmacokinetic properties and are active in an in vivo model of anxiety.
Liquid liquid partition chromatography was found to be a powerful tool for purification of compounds of this class.
Certain compounds of this class also showed in vivo activity in various human tumor xenograft models in mice.
