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It is our impression that some older people have difficulty answering the self report questions that define three of the five Fried criteria (unexplained weight loss, self-reported exhaustion, and low physical activity), and also that cognitive impairment compounds these difficulties.
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Persistent social pressures surrounding family obligations compound these difficulties, producing "care-giving hell" (Kaigo-jigoku).
Risk associated with depressive symptomatology in caregivers (parents and guardians) may further compound these difficulties.
Compounding these difficulties, time series or perturbation data is often difficult to obtain, either for ethical or technical reasons, from human in vivo biological states.
Compounding these difficulties of distance and transport to the hospital, the patients then encounter physical barriers in the form of poorly designed buildings.
Compounding these difficulties, experimental mouse models are lacking and diseased tissue for experimental analyses is typically obtained from patients with advanced disease at joint replacement surgery, thereby limiting insight to late stages of disease.
Compounding these difficulties are the lack of evidence-based approaches that have been widely integrated in health care for identifying and systematically addressing patients' affordability concerns and financial burden to promote compliance.
Compounding these difficulties for any inferential method is the effect of missing data; we have shown that this method results in essentially no missing data for targeted nuclear markers and chloroplast data (in contrast to a typical RNA-seq or RAD-seq experiment; see also Weitemier et al., 2014).
The inability precisely to date these texts compounds the difficulties that surround the attribution to a philosopher named 'David'David
These experiences compound the difficulties that these children may already have with stress-regulation, due to the atypical experiences that have led to the foster placement [ 23].
Although face recognition deficits in people with AD have traditionally been associated with memory impairments, our results suggest that an underlying problem with mental rotation may compound these recognition difficulties.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com