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However, there are few compounds that specifically target CA XII.
If so, he says, chelating compounds that specifically tie up copper and iron could be tested as potential Alzheimer's drugs.
Inhibitor compounds that specifically bind capsid proteins could inhibit virus replication at steps of assembly, receptor recognition or uncoating.
To identify chemical compounds that specifically bind to Tob, we screened 2000 fragments from The Drug Discovery Initiative (DDI) library that are soluble at 200 μmol/L in a buffer containing 5% DMSO.
These evidence suggest that compounds that specifically bind to peptides synthesized upon the sequence of such amyloidogenic protein stretches might also be able to inhibit amyloid formation of the corresponding full-length protein and, likely, amyloid-induced cytotoxicity as well.
The large number of chemical structures is the result of combinatorial chemistry of nature, which besides generating stereochemically complex structures with many functional groups, produce compounds that specifically interact with biological targets, and are used as templates for drug discovery [2].
Similar(26)
We searched for a compound that specifically inhibits MDM2 itself.
Another alternative approach is pretargeting, whereby tumour target antigen binding specificity is obtained by injecting unlabelled antibody derivatives followed by a radiolabelled low molecular weight compound that specifically binds to the tumour and is rapidly cleared from the circulation (Goodwin et al. 1986).
Phos-tag is a compound that specifically binds to phosphate groups.
bpV pic) is a small chemical compound that specifically suppresses PTEN activity (Rosivatz et al., 2006).
They use their model to identify doxorubicin as a compound that specifically interferes with GAr-mediated suppression of translation.
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