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Acids are chemical compounds that show, in water solution, a sharp taste, a corrosive action on metals, and the ability to turn certain blue vegetable dyes red.
Thiosemicarbazone chelators represent an exciting class of biologically active compounds that show great potential as anti-tumor agents.
Herein we report the structure activity relationships (SARs) of this novel class of dihydropyrone-containing compounds that show potent inhibitory activities against the HCV RNA polymerase in biochemical assays.
We also developed the required chemistry to elaborate this template with additional substituents and have used this chemistry to prepare some initial compounds that show selective inhibition of anaplastic lymphoma kinase (ALK).
Then, the focus was changed to compounds that show dual-target activity profiles.
Compounds constituting the mechanistic set were selected from a seed library of 37,836 compounds tested on the NCI human tumor 60 cell line screens and represent compounds that show a broad range of growth inhibition.
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Using Molecular Docking Simulations, we screened 120 native western himalayan medicinal compounds that showed affinity with EDA domain of Fibronectin.
The research team was able to analyze the factors that make for efficient ion conduction in solids, and home in on compounds that showed the right characteristics.
708,960 compounds that showed best predicted activities were chosen for further studies.
Recently we described a novel class of imidazopyridine compounds that showed exceptional anti-RSV potency in cell culture.
In two papers published recently in peer-reviewed organic chemistry journals, the Stierles reported finding two compounds that showed initial success in killing breast and ovarian cancer cells in lines maintained by the National Institutes of Health.
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