Compounds that specifically recognize GC base pairs usually have strong H-bond acceptors such as the furan in DB293.
Thus, we have been interested in the development of "antigen surrogates"; synthetic unnatural compounds that can recognize the antigen-binding sites of antibodies, BCRs, or TCRs with good affinity and selectivity.
We show that compounds assembled on-site that recognize structure have the highest potencies amongst small molecules and are similar in potency to a vivo-morpholino modified oligonucleotide that targets sequence.
We thus decided to use the PHD finger in a complex with HD1 for small-molecule screening, initially by taking an in silico approach, to see whether we could identify small compounds (up to 500 Da) that recognize the histone-binding surface of this complex.
In this study, we attempted to design and construct CYP199A2 mutants that recognize hydroxy aromatic compounds as substrates by protein engineering.
Efflux pumps are membrane transporters that recognize and export toxic compounds from the cell using the proton motive force.
One of the compounds that T2R38 recognizes, goitrin, is abundant in cruciferous vegetables, such as broccoli and Brussels sprouts.
Ebselen and Diphenyl Diselenide ((PhSe 2) are two organoselenium compounds that are recognized as promising pharmacological agents presenting antioxidant, anti-inflammatory, neuroprotective, and other beneficial properties [ 9].
According to their structure, phylogenetic position and class of microbial compound that they recognize, vertebrate TLRs can be classified into six subfamilies: the TLR1 subfamily encompasses TLR1, 2, 6 and 10; the TLR9 subfamily includes TLR7, 8 and 9; TLR12, 12 and 13 constitute the subfamily TLR11 and TLR3, TLR4 and TLR5 each form a subfamily [ 6, 7].
Automatic recognition of metabolic process concepts is performed by the built-in GGP recognizer of the GENIA Tagger and OscarMER that recognizes chemical compounds and action terms.
