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Tass reported that a special detachment of weather aircraft had been assembled to sprinkle clouds over the 18-mile danger zone with compounds that prevent rainfall.
For drug screens, they could re-create this stressful environment in a petri dish and then use holographic microscopy to look for compounds that prevent cell death.
Determining the temporal order of the early steps in the disease pathway will eventually lead to the development of drug compounds that prevent these steps from occurring.
Repellent compounds that prevent initial attachment of tick larvae offer a potential alternative to control with chemical toxicants.
Although several drugs are in development, no approved therapies for TTR amyloid cardiomyopathy are yet available, so the identification of additional compounds that prevent amyloid-mediated cardiotoxicity is needed.
Kamm says this environment could be useful in testing cancer drugs, as well as anti-angiogenesis compounds that prevent the development of blood vessels, effectively killing tumors by cutting off their blood supply.
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After screening ~5000 compounds, we identified 23 primary hit compounds that prevented the increased cell death in GLIS3−/− INS−GFP+ PP2-β cells (Supplementary Fig. 6c and Supplementary Table 8).
This group performed an extensive characterization of over 50 derivatives, several of which proved to be potent compounds that prevented tau aggregation in neuronal cell lines [ 38].
The advantages of the zebrafish were also employed in a small-molecule screen that identified 19 compounds that prevented dystrophic pathology in dystrophin-deficient zebrafish (Kawahara et al., 2011b).
Barter recommends treating them with chelated iron, an organic compound that prevents lock-up in the soil, allowing plants to absorb the iron they need.
The research has already led to the production and testing of some paper bags with the added chemical compound that prevents insects from reproducing, which had not been produced before, Brennan says.
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