Through a pilot screen of 2802 compounds from the National Cancer Institute (NCI) chemical libraries, we identified aclacinomycin (Acm) as a compound that preferentially affects ER function.
MDC is an autofluorescent compound that preferentially accumulates in mature autophagic vacuoles, such as autophagolysosomes.
In support of this notion, it is worth mentioning that unlike the lipophilic DiOC18, hypericin is an amphiphilic compound that preferentially locates to the polar aprotic zone adjacent to the lipid water interface (Lenci et al, 1995; Weitman et al, 2001).
The recent discovery of compounds that act preferentially on specific GlyR isoforms and the differential expression of these isoforms in distinct regions of the developing and adult CNS show considerable promise towards the development of drugs that act in defined glycine-mediated pathways.
An important goal in the field of CA is to identify, rationalize, and design potential compounds that will preferentially inhibit CA IX over all other isoforms of CA. The variations in the active sites between isoforms of CA are subtle and this causes non-specific CA inhibition which leads to various side effects.
The significant higher cumulative and net CO2-C efflux from the manure compared to that from the biochar amended soils were probably due to the former containing more easily mineralizable C compounds that were preferentially mineralized by microbes (Zavalloni et al. 2011).
By data mining the DTP archive, we are able to identify compounds that are preferentially toxic against the most tumorigenic of the NCI60 cell lines, based on the take rate of the cell lines in a mouse xenograft model.
We have identified cells with possible defects in the MRN complex and S phase arrest, and a series of compounds that may preferentially target S phase-defective cells.
In this study, we developed a high-throughput cell-based screening assay to identify compounds that are preferentially active against NB TICs.
We have identified cells with potential defects in the MRN complex and in S phase arrest, and a series of compounds that may preferentially target S phase arrest-defective cells.
