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These inhibitors were compared with reference compounds that lack one or both of the reactive centers.
Selective estrogen receptor modulators are estrogen-like compounds that lack the deleterious effects of estrogen.
Adding a linear hydrophobic tail para to the phenyl ring led to a new class of phenylthiazole antiflaviviral compounds that lack the toxic dibromomethyl moiety.
Inorganic compounds include compounds that are made up of two or more elements other than carbon, as well as certain carbon-containing compounds that lack carbon-carbon bonds, such as cyanides and carbonates.
Cortisone in recent years has fallen into disuse, as scientists have favored related compounds that lack side effects such as swelling.
Given these limitations of dopamine, there is an unmet need for compounds that lack hemodynamic action and yet are more efficacious than dopamine.
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GOLM Metabolome Database (GMD) (http://gmd.mpimp-golm.mpg.de/search.aspx) and the Guineu program [ 36] were utilized for second-stage identification of those compounds that lacked spectral matches with compounds from the NIST05 or in-house collected libraries.
While these differences may be due to the absence of the associated cyclin, a recent screen against LmCRK3-cyclin 6 also resulted in compounds that lacked efficacy against cultured L. major.
Another Biofil recipient in Ayidiki, George Clottey, lived in a compound that lacked adequate space for a conventional septic tank or latrine.
The compound that lacks the phenol group is 4-isopropylphenol [HO-C6H4-CH(CH3 2], and this para-isopropyl phenol was fairly potent at displacing [H]BPA, with an IC50 value of 71.1 nM (Table 2).
It should be noted that all of the abovementioned tests are associated with certain limitations, such as over-sensitivity for acutely toxic compounds, over-sensitivity for compounds that are irritating/corrosive, lack of metabolism, water solubility, etc.
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