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The differences in binding affinity for these two compounds that differ only at the central heterocycles are striking.
Asymmetric synthesis, any chemical reaction that affects the structural symmetry in the molecules of a compound, converting the compound into unequal proportions of compounds that differ in the dissymmetry of their structures at the affected centre.
A recently suggested approach for the analysis of chemical datasets uses pairs of compounds that differ by a small single point change only.
Here we show that the potency, selectivity, and kinetics of asPTP inhibition can be significantly improved by exploring the inhibitory action of a range of biarsenical compounds that differ in interarsenical distance, steric bulk, and electronic structure.
We demonstrate here the versatility of cation-exchange chromatography and pulsed amperometric detection of a range of compounds that differ in both isometric structure and N-alkyl chain length.
More than half of SCCs responded to various bitter compounds that differ in structure.
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Substantial differences in gene regulation could be observed with compounds that differed by as little as a single methyl group.
The first axis discriminated samples from the IR64 irrigated treatment, the second discriminated IR64 drought samples from the two Apo treatment classes, while the third described those compounds that differed between the two treatments applied to Apo.
Synthesis and testing of fourteen compounds that differed at the pendent amine led to the identification of an agent (14) with 2 μM activity against AML cancer cells and an eleven fold-lower activity in healthy CD34+ blood stem cells.
In 1966, Joel E. Goldmacher and Joseph A. Castellano, research chemists in Heilmeier group at RCA, discovered that mixtures made exclusively of nematic compounds that differed only in the number of carbon atoms in the terminal side chains could yield room-temperature nematic liquid crystals.
Moreover, the proportion of alleles that differed between supercolonies pairs was positively correlated to the proportion of CHC compounds that differed between supercolony profiles (r = 0.26, p = 0.044).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com