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This chapter restricts itself to compounds that act directly on the bacteria.
From this library, we identified 13 compounds that act as putative FXR transcriptional antagonists.
For example, plants in the cabbage family contain sulfur-containing compounds that act as sign stimuli for insects that habitually feed on only these plants.
Special attention is also given to compounds that act as multiple inhibitors of two, three or more of the Mur enzymes.
Designing compounds that act as substrates for efflux transporters in the blood brain barrier can achieve CNS restriction without significantly impairing absorption in the intestine.
However, a significant challenge with lignocellulosic feedstock is the presence, after hydrolysis, of weak acids and phenolic compounds that act as microbial inhibitors (Olsson and Hahn-Hägerdal 1996; Palmqvist and Hahn-Hägerdal 2000; Taherzadeh et al. 1997).
The pipeline for development of other classes of effective antimalarials, especially compounds that act against novel biochemical targets, is limited.
We have previously hypothesized that such damage can either be attenuated or reversed by compounds that act as mobile electron and proton carriers [11].
There are several natural and synthetic compounds that act as proteasome inhibitors.
Other compounds that act on chloride channels produce similar anxiolytic-like effects as the FAT-M.
We examined the effect of phenanthridine-derived compounds that act as potent PARP inhibitors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com