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However, the presence of substructure patterns in compounds specific to their individual target is more important to predict their activity.
These findings led the researchers to suspect that compounds specific to the foreign fungus were inhibiting the growth of the in-house fungus.
This could be due to the fact that compounds specific to the targets and assays as such do not have any associated toxicity related alert.
Extending this idea to Plasmodium-infected cells we propose that future screens aimed at finding such new anti-plasmodial molecules should include more small hydrophilic metabolite-like compounds specific to 'parasite-only' pathways (e.g. from the apicoplast; [13]) in their chemical libraries (in contrast to the current situation; see [47], [48] for a general discussion).
The second function describes the aspects of compounds specific to each cell line.
To determine compounds specific to groups defined by nMDS and confirmed by perMANOVA, we used the indicator value (IndVal) method [ 124].
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Some acid stream compounds are specific to higher plants with the polycyclic terpene phytosteroids such as campesterol, stigmasterol and β-sitosterol detected in the microbial mat samples FlowMG1a, FlowMG2a, FlowMJ1a and DryMJ1a.
The chemical space represented by these compounds is specific to the pharmaceutical industry and it was interesting to analyse how different models project from the public training space onto this confidential test space.
A common question in chemical screening is whether the identified compounds are specific to zebrafish, and how the results of zebrafish chemical screening compare with mammalian cell line based chemical screens.
The drug effect can be abrogated when RAD51 is knocked down by siRNA, suggesting the mode of action of the compound is specific to RAD51.
One hit was active in zebrafish embryos and zebrafish cell culture, but not in mammalian cell culture, suggesting the target of the compound was specific to the zebrafish and not conserved in mammalian cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com