Sentence examples for compounds should have from inspiring English sources
The best regressive model revealed that potentially more active compounds should have low dipole moments and QC-min (minimal net atomic charge for a C atom), and high QO-max (maximal net atomic charge for an O atom) and QN-min (minimal net atomic charge for an N atom).
Active compounds should have a pXC50 no less than 5 and only targets with at least 20 active compounds were considered.
Hence, the results of an in silico model can be used to suggest which chemical compounds should have a higher priority to be further tested by the more expensive but more accurate in vivo and in vitro experiments.
According to the rule, compounds should have no more than five hydrogen-bond donors, no more than ten hydrogen-bond acceptors, have a calculated LogP of no greater than five and a molecular mass of no more than 500 Da.
Web search and VS can be treated as a similar problem, seeking an analogous result where higher candidates (webs or compounds) should have higher relevance to the underlying target (query or protein).
It has been suggested that passively absorbed compounds should have a maximum TPSA of 120 Å2.
Our previous work on pyridazinone arylpiperazine derivatives suggested some structural features that a compound should have to show high affinity and good selectivity for α1 adrenoceptors (AR) with respect to α2-AR.
An ideal compound should have weaker inhibitory effects and higher enhancing activity (Wang et al, 2009).
Therefore, removing it from any compound should have no impact on choices: The participants' behavior should be largely similar when deciding between AB and CE and when deciding between AB and C.
Based on the above findings that SYK inhibition by RO9021 is able to impinge on several innate and adaptive immune responses, we speculated that the compound should have therapeutic efficacy in an autoimmune disease model.
