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Pthalocyanine and porphyrin derivatives were the compounds selected for the respective comparative study.
The two CTA compounds selected for this study differ in their peripheral substituents: aliphatic (-C10H21) and fluorinated chains (-CH2C6F13), respectively.
Compounds selected for in vivo evaluation exhibited a significant antitumor activity on three tumor models at well tolerated doses, thus suggesting a good therapeutic index.
Of 16 diverse compounds selected for experimental screening, 2 prevented and reversed Aβ aggregation at 2 3 μM concentration, as measured by Thioflavin T (ThT) fluorescence and ELISA assays.
The best three compounds selected for in vivo pharmacokinetic testing all showed high oral bioavailability, with one notable compound showing a significantly longer half-life and good tolerability supporting its further advancement.
The five compounds selected for these tests based on their low potential toxicity, commercial availability and predicted potency demonstrated varying levels of specificity and efficacy.
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Abbott-232 is a chemically stable, highly water soluble non-hygroscopic compound selected for development as a potent uroselective α1A agonist.
The new compound selected for study in this report, BJE6-106, is much more potent than rottlerin.
Triadimefon was the second compound selected for PK modeling because it represents a specific NCC toxicant (Zimmer et al. 2012; Menegola et al. 2005).
This new class of sterically hindered platinum compound, selected for clinical trial in 1997, may therefore elicit improved clinical response in intrinsically and acquired cisplatin-resistant tumours in the clinic.
Among 14 compounds only 10 compounds were selected for anticancer screening.
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