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In 2008, the Open Notebook Science Solubility Challenge was launched for the purpose of measuring non-aqueous solubility of organic compounds, reporting all the details of the experiments in an Open Notebook and recording the results as Open Data in a centralized database [78, 79].
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Compounds reported as active in both AR agonist and antagonist screens.
Open image in new window Fig. 1 Structures of the compounds reported in this paper.
The title compounds reported in the present work were prepared by the following procedure [19, 20].
Compounds reported here can serve as promising leads for further study.
N-alkylation of the series of the compounds reported previously (N-unsubstituted) resulted in improved activity.
For the dataset on nephrotoxicity, we also included compounds reported to have effects on the urinary tract.
The diffraction peaks of the crystalline phase were compared with those standard compounds reported in the JCPDS Date file.
(DOC 160 KB) 13065_2011_339_MOESM2_ESM.DOC Additional file 2: Supporting Information File 2. This contains NMR spectra for all the compounds reported.
The spiro compounds reported in the present work were prepared (Scheme 1) by following our earlier literatures method [6 8].
Among the compounds reported to bind σ receptors, a large number of benzylpiperidine and benzylpiperazine derivatives display remarkable affinity.
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