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To investigate this issue, we determined if these ERβ-selective compounds regulate the same or different genes.
JA compounds regulate the biosynthesis of many different types of secondary metabolites in different plant species including alkaloids, terpenoids, glucosinolates, and phenylpropanoids.
These compounds regulate the expression of a large number of bacterial genes, including those associated with virulence in human pathogenic organisms.
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The HFE gene, together with other biologically active compounds, regulates the intestinal absorption of iron [ 1, 2].
Triterpenoid compounds regulating the activation of myeloid cells, including MDSCs and TAMs, are potential candidate agents for anticancer therapy.
The representative compound regulated the expression of genes involved in lipid and glucose homeostasis, and should be useful not only as a chemical tool to study PPARδ function, but also as a candidate drug for the treatment of metabolic syndrome.
Finally, the combination of TGF-β and off-target signatures revealed that some compounds regulate genes inverse to the desired therapeutic effect (Fig. S5d).
These compounds regulate colon carcinoma cell gene expression, survival, differentiation, proliferation and invasion and inhibit angiogenesis and metastasis during colon cancer progression.
Clearly the skin is an important estrogen target tissue, yet we still do not fully understand the molecular processes involved and the mechanisms by which estrogens and related compounds regulate skin function and delay skin aging.
To explore whether these compounds regulate insulin gene transcription in islet β-cells, a luciferase reporter gene under the control of mouse insulin gene promoter 1 (Ins1) as well as insulin gene promoter 2 (Ins2) were co-transfected into NIT-1 cells.
Future studies should address the molecular mechanisms by which these plants and their active compounds regulate glucose uptake by adipose and muscle tissues.
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