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The compounds provide a starting point for the synthesis of novel tools to decipher Hsp70 biology.
The binding modes of the hit compounds provide a platform for development of selective small molecule inhibitors of HSPA5.
The identified compounds provide a rational basis to initiate the design and chemosensory analysis of new low-calorie sweeteners.
The bioactive compounds present in these compounds provide a variety of physiological functions, for instance, antimicrobial, antiallergenic, anti-inflammatory, and antimutagenic effects [5].
The multiple secondary metabolites in Citrus, including flavonoids, alkaloids, coumarins, limonoids, carotenoids, phenolic acids and volatile compounds, provide a rational basis for various biological activities.
Our initial results show that promising ligands can be identified by adding discriminating fragments to a core scaffold and that the generated compounds provide a reasonable synthetic accessibility.
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These compounds provide an example of polycentric bonds, which cannot be properly represented in SMILES format.
This new X2YZ compounds provide an alternate platform for novel quantum phenomena and multifunctional topological devices.
The systematic predictions of elastic properties and enthalpies of formation for Al X compounds provide an insight into the understanding and design of Al-based alloys.
When combined with reaction films from antiwear additive such as zinc dialkyl dithiophosphate (ZDDP), the soft organometallic compounds provide an easily shearable sacrificial layer and the inorganic phosphate glassy structure provides the load carrying capacity.
As outlined in the previous sections, the fundamental results for neutral compounds provide an improved understanding of the radical cation formation process for carotenoids, namely β-carotene.
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