Sentence examples for compounds on both from inspiring English sources

The best compounds on both series show IC50 values between 3 and 8 nM.

Molecular docking studies of these compounds on both targets were also conducted and encouraging results were acquired.

Dannhardt et al. [83] highlighted the key role of the carbonyl moiety for the potency of a series of diarylmethanone compounds on both COX isoenzymes.

Except for compound 3b which is inactive at the concentration tested, the antiproliferative activity of all compounds on both human mammary carcinomas cell lines are in micromolar range and are more active than carboplatin and oxaliplatin alone but less active that their E-CDDP counterparts (1 3).

During the method development, the LOQ was calculated for all compounds on both instruments.

All the models have been tested using training sets of different sizes and multiple sets of 20 randomly selected basis compounds on both compound sets.

8b was the best active compound on both HCT116 and HEPG-2 cancer cell lines; its IC50 is 26.5 and 12.3 nM/ml respectively.

Furthermore, the carbamates 8, 9 and 11 were able to inhibit Aβ42 self-aggregation and possessed quite low toxicity against human astrocytoma T67 and HeLa cell lines, being the carbamate 8 the less toxic compound on both cell lines.

This effect being compounded on both chains causes a complete disruption of Zn2+ binding and destabilization of the dimer.

The identification of Ro 31-8220 in our screen for compounds that affect nuclear foci demonstrates an important role for this compound on both MBNL- and CELF1-dependent events in DM, highlighting it as a good starting point for a drug discovery programme.

We use the proportion of reactions that have a dead-end compound on one or both sides as a proxy for the overall reliability of the network.