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Furthermore, the HTS assays were very useful for quickly identifying compounds of potential risk for further studies, thus concentrating resources on the potentially most significant chemicals.
This work demonstrates the utility of zebrafish as a screening tool for small molecules that affect eye vasculature and presents several compounds of potential therapeutic importance.
According to our results, the design of molecules with the side chain bound to the ethylene part of the triphenyl ethylene skeleton might generate compounds of potential pharmacological interest.
Recently also a number of other synthetic imidazole and pyridine based compounds of potential insulin-mimetic activity have been studied in solution [16]-[17] [16]-[17]
The collaborative NormaNEWS [25] joint activity has already successfully demonstrated the usefulness of the retrospective screening of high-resolution mass spectrometric data in establishing the spatial and temporal occurrences of newly identified compounds of potential emerging concern [26].
Future work will involve screening of larger and more relevant chemical compound libraries with a view to identifying lead compounds of potential clinical significance.
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The system, in fact, was constituted by a recombinant phosphoenolpyruvate carboxylase (PEPC) from the thermophilic cyanobacterium Thermosynechococcus elongatus, in combination with mesophilic/thermophilic bacterial carbonic anhydrases (CAs), for converting CO2 into oxaloacetate, a compound of potential utility in industrial processes.
To date, only a few noncovalent inhibitors of PBPs have been described[7] [9], and so we screened our in-house bank of compounds for potential inhibition of this important drug target.
The environmental concern is because most of the agro-industrial wastes contain phenolic compounds and/or other compounds of toxic potential; which may cause deterioration of the environment when the waste is discharged to the nature.
This study aimed to identify antifungal drugs and antiseptic compounds for potential treatment of geomycosis and decontamination of Gd.
Identifying promising compounds from a vast collection of potential compounds is an important and yet challenging problem in chemical engineering.
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