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These two companies aren't developing brand-new therapies; instead, they're finding ways to deliver existing compounds more efficiently.
Although the potential microorganism P. aeruginosa was capable of biodegrading all the selected organic compounds up to 750 mg/L, the microbial consortium degraded the selected compounds more efficiently and rapidly than the potential microorganism at all the selected concentrations (Table 1).
To predict and cluster biologically active compounds more efficiently, the concept of basis compounds is proposed that enables researchers to easily combine the MCS-based and traditional similarity measures with modern machine learning techniques.
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The team of scientists, led by Joerg Bohlmann, professor of Botany and Forest Services, has successfully identified the gene encoding for cis-abrienol, the key chemical compound in balsam fir and can now introduce the gene into a yeast strain familiar to winemakers to reproduce the compound more efficiently and more reliably than ever before.
Solid phase synthesis of compounds 2 proceeds more efficiently than of compounds 3 under similar conditions.
In total, three compounds activated the two ER subtypes equally (BP-2, 4-OP, and BBP), two compounds activated ERβ more efficiently than ERα (BPA and butylparaben), and seven compounds activated ERα more efficiently than ERβ (ferutinine, α-ZA, BPC, TCBPA, DDE, chlordecone, and HPTE).
The double-charged compounds condensed DNA more efficiently than single-charged and the condensation increases with the increasing +/− charge ratio between the carrier and DNA.
Hence, these effects were greater for compounds that were more efficiently packed carboxylates [98].
Improvements are also likely due to pulsed splitless injection over previous nonpulsed splitless injection [ 13, 14, 17] by getting compounds in column more efficiently.
Some compounds appear to more efficiently activate human compared with rodent PPAR-α in vitro, as was demonstrated for the synthetic polyunsaturated fatty acid 5,8,11,14-eicosatetraynoic acid in transfected human liver cancer HepG2 cells (Mukherjee et al. 1994) and for perfluorobutane sulfonate in transfected COS-1 monkey kidney cells (Wolf et al. 2008).
These compounds also photocleaved DNA more efficiently than their corresponding naphthalimides.
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