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These findings indicate that the active diarylheptanoid compounds may provide valuable lead for design and development of new antifilarial agent(s).
A systematic identification of interacting compounds may provide a means to purify more proteins, as well as a method to ascribe function to new proteins.
As it is commonly believed that formation of oligomers is related PD progression, such compounds may provide a promising strategy for the design of novel therapeutic drugs in Parkinson's disease.
The 3D-QSAR study of these compounds may provide useful information for the development of novel aryl-piperazines as uro-selective α1-adrenoceptor antagonists, which can be used for the treatment of BPH with fewer side effects.
Saccharin (SAC) based compounds may provide an avenue to overcome CA isoform specificity, as they display both nanomolar affinity and preferential binding, for CA IX compared to CA II (>50-fold for SAC and >1000-fold >1000-folds conjugated to a carbohydrate moiety).
Because HPPD inhibitors are extensively used as herbicides and in medicine, these compounds may provide an alternative less toxic to humans and more environmentally friendly than the conventional neurotoxic insecticides that are currently used, with the ability to affect only hematophagous arthropods.
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This natural dietary compound may provide a novel alternative therapeutic strategy in inflammatory diseases such as inflammatory bowel diseases.
This natural dietary compound may provide a novel alternative therapeutic strategy for inflammatory diseases which involve oxidative stress such as IBD, rheumatoid arthritis and atherosclerosis.
This hit compound may provide a new avenue for the design of potential selective inhibitors of the p53-Mdm4 interaction.
These findings demonstrate that treatment with the δ-tocotrienol oxazine derivative, compound 44, significantly attenuates +SA mammary tumor cell compensatory responses to hypoxia and suggests that this compound may provide benefit in the treatment of rapidly growing solid breast tumors.
This compound may provide an effective means of treatment for refractory organ-infiltrating leukemias and is potentially important for optimizing the therapeutic combination of vascular targeting agents with radiotherapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com