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The molecular properties of the compounds, important for drug pharmacokinetics and biodisposition in the human body, were assessed by the Lipinski's rule of five.
To elucidate the structural properties of these compounds important for antibacterial activity, comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were applied to a set of 56 aminoglycosides mimetics.
The ToxCast data set therefore represents an important and evolving basis for evaluating computational methods used in toxicological assessments of compounds important for environmental and health applications.
Stored seed transcripts, like other compounds important for early seedling establishment, are deposited after embryogenesis and during seed maturation [ 54, 55] and previous studies have found that expression profiles of stored seed transcripts respond to the parental environment [ 35, 50].
Primary and secondary compounds important for grape and wine products begin to accumulate in the exocarp and/or the mesocarp at ripening initiation [ 10], so we considered that it was important to evaluate changes in the berry proteome separately in these tissues.
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TLC can be used in those situations when HPLC-UV and GC are not suitable, for example, absence of UV activity of examined compound (important for HPLC analysis) or when the absence of volatility (important for GC analysis) is observed; in comparison to HPLC in the case of TLC the high purity and high concentration of examined samples are not required.
The specificity and activity of the gyramides for inhibiting gyrase makes these compounds important chemical tools for studying the mechanism of gyrase and the connection between DNA topology and bacterial cell division.
The novel technique may be useful for making compounds important in agriculture and pharmaceuticals with less damage to the environment.
The thermo-mechanical properties of these compounds are important for the assessment of package reliability.
Also, dependable observation of the unbound compounds is important for ligand-based drug discovery, e.g. with pharmacophore modelling.
The substitution of the group at the 8a-position of compounds was important for its lipid-lowering activity, and the SAR was discussed.
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