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"I think it will change how people think about how these compounds function," he says.
(Scientists are actually still evaluating how these compounds function in humans).
Exogenous serotonin and octopamine elicit specific and opposite behavioral responses in Caenorhabditis elegans, suggesting that these compounds function physiologically as antagonists.
We demonstrate that the designed compounds function as type II inhibitors by using biochemical and cellular kinase assays and by cocrystallography with Abl.
Results are also presented that suggest the compounds function through a unique mechanism of action as compared to that of related acridine and xanthone anticancer agents (which have been shown to intercalate into DNA and inhibit topoisomerase II activity).
Comparison between survival plots and relative ID50, obtained from the K-562/doxR cells treated with Idarubicin (IDA), in the presence or absence of inhibitors, showed that these compounds function well.
Similar(28)
A working model of how this class of compounds functions to antagonize the AR was created.
Some of these compounds functioned as potent inhibitors against the proliferation of endothelial cells and cancer cells but possessed much weaker cytotoxic activities against non-cancer cell line of CCC-HPF-1.
In the latter case, a layer of dead organisms would have protected organisms underneath by compounds functioning as UV shields [41].
Compounds functioning as agonists activate signal transduction within the cells, leading rapidly to depolarization-driven calcium influx and a reduction of fluorescence at the monitored wavelength.
The application of compounds functioning as enhancers of the antioxidant enzymes expression or activity may constitute a class of potential drugs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com