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Compound 1 was discovered from focused screening of serine protease-directed compounds from our internal collection.
Although various physicochemical methods have been used to remove these compounds from our environment, they have many limitations.
Compounds from our laboratory database, including natural products and anticancer agents, were employed for the docking analysis.
Using competitive activity-based protein profiling (ABPP) to identify novel inhibitors of human (h ABHD11, three compounds from our chemical library exhibited low nanomolar potency towards hABHD11.
Compounds from our laboratory database and two control kinase inhibitors, Tarceva and Iressa, were employed to dock into the HER2 ATP binding site.
Comparison of docking studies on different stereoisomers of R207910 as well as compounds from our data set, suggests importance of electrostatic interactions.
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Our ongoing battle to remove the Libyan compound from our community and my personal battle to evict them as my direct next-door neighbor is a David-and-Goliath struggle, a small New Jersey town and a father of nine against an oil-rich Middle East dictator who is currently being courted by Western leaders.
All alcohols used as reference compounds were from our laboratory collection of pheromone compounds.
Improved compounds, derived from our Sirt2 inhibitors or identified through docking more drug-like compounds to their putative binding site, would be helpful for functional studies and promising for therapy.
Group III compounds, which do not exhibit tumor-specific activity like compound M from our previous study, are compounds F4, F5, F6, F7, F8, H3, H4, H7, H8, and N1.
These compounds resulted from our efforts to merge the pharmacophores of selective factor Xa inhibitor rivaroxaban with a mimic of the Arg-Gly-Asp (RGD) sequence of fibrinogen to obtain designed multiple ligands with potential antithrombotic activity.
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