Sentence examples for compounds focus from inspiring English sources
Many studies using natural substances and herbal compounds focus on the activity of the PI3K/Akt signaling pathway in preventing obesity; hormones and growth factors that are specific to adipogenesis act via their receptors to transduce external differentiation signals through a cascade of intracellular events in the PI3K/Akt signaling pathway [ 32].
Biological evaluation of these compounds focused on maintaining activity while improving pharmacokinetic (PK) properties.
Our searches for specific STAT-targeting compounds focused on exploring the phosphotyrosine (pTyr) SH2 interaction area.
The in vitro evaluation of the compounds focuses on GST inhibition and stability towards γ-glutamyl-transpeptidase (γGT), the main enzyme involved in GSH breakdown.
This compound collection of a total of 432 compounds focuses on eight targets belonging to four protein families and has enabled us to evaluate different in silico approaches to search for target-selective compounds [3].
The determination of all the dangerous properties is a long and difficult task, thus it is very important to have tools to quickly screen and highlight the most hazardous compounds, focusing the experiments only on the prioritized compounds.
We examined SAR of the synthesized compounds focusing on substitution at the three aromatic parts of the starting compound 1 and succeeded in identifying essential substituents for inhibition of ACAT and up-regulation of hepatic LDL receptor expression.
In addition a different group of 28 substituents are identified as unlikely to change in vitro HLM stability, and a further set of compounds focuses on increasing HLM stability only.
A novel series of oligothiophene compounds focused on the target were synthesized as specific inhibitors against the H5 subtype of influenza A viruses because oligothiophene has stronger π π interactions with residues F1102 and M241 of HA2 side chains.
The library contains several distinguished subsets such as (1) known bioactive compounds such as toxins and drugs, (2) natural products, (3) compounds focused on a variety of biological target families and (4) large number of compounds attributing to a significant diversity.
The Kozikowski laboratory has synthesized a number of compounds focusing on HDAC6.
