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BASs were successfully extracted from chemical compounds exhibiting a diverse array of structural features.
The aim of this research was to design new compounds exhibiting a double profile of hypoglycemic agents/NO-donors.
Seaweeds are potential sources of high biotechnological interest due to production of diverse compounds exhibiting a broad spectrum of biological activities.
The results of different studies describe the N-heterocyclic ring system is a core structure in many synthetic compounds exhibiting a broad range of biological activities.
The cathodically induced coupling of α,β-unsaturated esters and allyl bromides to form compounds exhibiting a new C C bond is transferred from galvanostatic, macroscopic conditions (as described in the literature) to potentiostatic control in a micro-electrochemical screening environment (microtiter plate wells, 200 μl electrolyte volume).
Compounds exhibiting a high potency (IC50<15 µM) and no cytotoxicity (based on PI exclusion) at IC50 were isolated as final hits.
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In addition, the compounds exhibit a favorable polarity profile.
Both compounds exhibit a relatively high degree of crystallinity (∼30%).
None of the isolated compounds exhibited a significant antifungal activity [133, 134, 135].
On the other hand, the other types of toxic compounds exhibit a variable behavior.
These compounds exhibit a broad spectrum of activities including antimicrobial, antifungal, and antiviral ones.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com