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Calibr scientists will then use their suite of high-tech robotic equipment to screen novel compounds, evaluate their toxicity and safety in animals, and prepare any compounds for human clinical trials.
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Among the compounds evaluated, twelve compounds exhibited IC50 < 0.1 μM and may be considered as high potency inhibitors.
Of the compounds evaluated, compound 32 was as potent as the standard compounds against VEGFR-2 and PDGFR-β, showing dual inhibitory activity against RTK.
On the other hand, both lights stimulated the synthesis of all bioactive compounds evaluated and consequently the antioxidant capacity.
The micellization behavior of the compounds, evaluated from surface tension measurements, is presented and compared to more conventional ionic amphiphiles.
Out of 24 compounds evaluated, 12 compounds potentiated the activity of ciprofloxacin and resulted in 2 16 fold reduction in the MIC (4 0.5 μg/mL) of the drug.
A third of the compounds evaluated failed to crystallize after 1 h, while the remaining compounds crystallized at intermediate time points.
Eucalyptol was the bicyclic terpenoid most active against pupae, the only activity lower than 100 μg/mL of all bicyclic compounds evaluated.
The compounds evaluated during the preliminary experiments showed a high uptake in non-target organs caused by their relatively high lipophilicity.
For comparison purposes, all compounds evaluated in these studies were also tested against HIV-1LAI in primary human lymphocytes.
Drug activity was found to be far more pronounced for all compounds evaluated in the GKO mice when compared to the immunocompetent C57BL/6 mice.
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