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While these compounds establish in principle that Hsp90 is a "druggable" target from a pharmacology perspective, poor solubility and non-specific toxicities make them unsuitable for use in humans.
The actions of these compounds establish the principle that small molecules can produce potent upregulation of 14-3-3 14-3-3 14-3-3nd point to thexpressionity of developing andseful human neuropointctove agenthehat uses this mechanism.
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The ionization potentials of the synthesized compounds established by photoelectron emission technique in air ranged from 5.35 to 5.66 eV.
Current studies have revealed that these compounds established stronger hydrogen bonding networks with active site residues as compare to the standard compound 7DX.
The ionization potentials of the solid samples of the compounds established by electron photoemission spectrometry in air ranged from 5.57 to 6.01 eV.
Remarkably, these compounds established agreeable interactions with the amino acid residues Phe67, Asp63, Thr59, Gly64, Ile66, Phe99, Arg123, Asn119, and Gly120; which are found to play a vital role in the LuxT mechanistic inhibition.
Successfully classifying similar compounds establishes that observed transcriptional responses reflect an underlying mode of action.
The analysis is based on a tolerable intake level for dioxin-like compounds established by the World Health Organization and on risk estimates for human exposure to dioxins developed by the U.S. Environmental Protection Agency.
Through "slow and controlled delivery," this compound establishes its own "equilibrium" so as to maintain the sustained-yet-tasteful release of odor-fighting fragrance.
In our study, docking of novel compound with 2ZJ4 showed binding interaction of Keto group of the novel compound established the hydrogen bond with SER 473 which is the major interaction of the ligand with 2ZJ4.
They then moved in to clear compounds and establish patrol bases in the area.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com