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Most of the compounds engage H6 NH for hinge recognition.
The microtubule targeting compounds engage at the mitotic spindle checkpoint where they block cell cycle progression at mitosis ultimately leading to apoptosis (Bhat and Setaluri [2007]).
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Al Shabaab fighters then entered the compound, engaging in a gunfight with security forces for over ninety minutes.
But guards at the compound engaged in a firefight, driving away the gunmen, Deputy Interior Minister Mohammad Ayub Salangi told reporters at the scene.
Shot in 35 millimeter in the filmmaker's preferred brackish tones, "The Sun" traces Hirohito as he wanders about his compound engaged in meaningless rituals and surrounded by minders who are as much his guards as his servants.
Restoration of protein synthesis by both agents was effaced by washing cells free of the compound before thapsigargin application, indicating that both compounds reversibly engage their target in vivo.
To determine whether compounds 1– 11 engage the same site on DHPS as suggested by their similar structures, selected compounds were soaked into BaDHPS crystals and the complex structures were determined.
There is a resurging interest in compounds that engage their target through covalent interactions.
Finally, an exploration of the correspondence of binding affinities to in vitro functional activity reveals an additional layer of complexity central to prospectively designing compounds to engage multiple targets.
February 21 , 2014 Al Shabaab attacked Villa Somalia, the presidential palace compound, with a car bomb before entering the compound to engage in a gunfight with guards.
Considering that loss of tumor suppressor beclin 1 is associated with neoplasia, the ability of this small molecule compound to engage both autophagic and apoptotic machineries via ROS production and subsequent activation of ERK and JNK could have potential translational implications.
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