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Co-crystal structures of TAK1 with candidate compounds enabled iterative rounds of structure-based design and biological testing to arrive at optimized compounds.

Dereplication of the photo-cytotoxic fractions from P. ophthalmicus extracts based on TLC Rf values and HPLC co-injection of reference tetrapyrrolic compounds enabled quick identification of known photosensitisers, pheophorbide-a, pheophorbide-a methyl ester, 132-hydroxypheophorbide-a methyl ester, pheophytin-a and 151-hydroxypurpurin 7-lactone dimethyl ester.

Harnessing promiscuous intermolecular reactions of carbenoid compounds enabled highly efficient exploration of chemical space.

These novel compounds enabled to perform additional microarray preparations and binding experiments.

These compounds enabled a good understanding of the exchange interactions to be determined, by fitting to magnetic data.

The incorporation of fluorine-containing compounds enabled highly sensitive and specific detection of microstructures in physiologic settings using fluorine MRI techniques (F MRI).

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Similar vapor pressures in the two compounds enable simultaneous evaporation in addition to a compositional control of PbTe.

The formation of blue compounds derived from FC-reactive phenols was independent of the structures of the phenolic compounds, enabling quantification of the full complement of phenolics from plant extracts.

The increasing availability of data on characteristics and functions of biomolecules and small chemical compounds enables researchers to better understand various chemical, physical and biological processes or activities with the use of machine learning methods [1 7].

In contrast to "wet" experiments, computational (in silico) prediction of xenobiotic metabolites can be applied to virtual (not yet synthesized) compounds, enabling the optimization of the drug discovery process and generating a priori knowledge of metabolites that may be used for the creation of prodrugs.

The method, which involves amplifying BSE PrPSc in the presence of sulfated dextran compounds, enables sensitive detection of PrPSc at levels equivalent to those obtained for detection of hamster PrPSc [19].

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