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The compounds demonstrated high thermal stability.
All the tested compounds demonstrated potent cytotoxicity against HCT 116.
Together with anticancer effect, some compounds demonstrated anti-angiogenic properties.
Both compounds demonstrated activity against Staphylococcus aureus and Candida albicans [77].
The measured response factors for the model tar compounds demonstrated very good linearity.
The designed compounds demonstrated low to moderate cytotoxicity in several cell lines.
Most of the new compounds demonstrated high in vitro antibacterial activity.
The most potent compounds demonstrated selectivity towards isoform I and affinities of 0.5 nM.
Some compounds demonstrated competitive antiproliferative activities to sorafenib against all three cancer cell lines.
All compounds demonstrated good dipeptidyl peptidase IV (DPP4) inhibitory activities (IC50 = 0.004 113.6 μM).
Furthermore, an ulcerogenicity study was performed where the tested compounds demonstrated a significant gastric tolerance.
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