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Sequence analysis reveals that many of the kinases that are potently inhibited by the isoquonoline-containing compounds contain a long insertion within their catalytic domains.
This is not because the compounds contain a chemical that provides some essential nutrient.
Here, 28 compounds contain a halogen element.
The 18 Allergan discovery compounds contain a variety of chemical moieties.
The compounds contain a triazole core that is readily assembled via Cu-catalyzed click chemistry.
These compounds contain a core phenanthrene structure and can be synthesized efficiently in excellent yield.
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Alkenes are the customary starting materials from which epoxides, compounds containing a three-membered ring consisting of one oxygen atom and two carbon atoms, are made.
CHEBI 36786 tetralins Compounds containing a tetralin skeleton.
Many active compounds contained a C-alkylthiazole building block.
Compared with compounds containing a very small aromatic core (benzene group), compounds containing a much larger aromatic core (1,3,5-triphenylbenzene group) had better gelation ability.
CHEBI:51586 benzoins Compounds containing a benzoin (2-hydroxy-1,2-diphenylethanone) skeleton.
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