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Previously, Lin reported that W. chinensis contained four compounds capable of suppressing androgen activity: luteolin, apigenin, indole-3-carboxyaldehyde and wedelolactone [ 12].
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We show that pepstatin A, a potent but virtually insoluble inhibitor of cathepsins D and E, can be conjugated to a single site on cystatin C, a potent inhibitor of the papain-like cysteine proteases (PLCP) and of asparagine endopeptidease (AEP), to create a highly soluble compound capable of suppressing the activity of all 3 principal protease families found in endosomes and lysosomes.
This led to the identification of compounds 3a and 3b, which were capable of suppressing both c-Met and VEGFR2 kinase activities.
These Tregs possess potent suppressive activity and are capable of suppressing acute liver allograft rejection.
Curcumin metabolites were much less capable of suppressing COX-2 transcription in cells in vitro than the parent compound (Ireson et al, 2002), indicating that chemopreventive efficacy may be in the main mediated by curcumin per se and that metabolic conjugation and reduction constitute pharmacological deactivation steps.
Furthermore, the development of models capable of distinguishing compounds capable of activating T-cells need to be developed.
We recently identified niclosamide, perhexiline, and rottlerin as compounds capable of rapidly inducing autophagy [43].
They identified two novel compounds capable of lowering blood glucose, but these compounds also paradoxically activated pck1 expression.
Four hit compounds capable of inhibiting >50% of the radioligand binding were examined further.
Antiviral research on HSV preliminarily focuses on compounds capable of targeting the viral polymerase.
This led to clinical studies with several compounds capable of inhibiting NO synthesis.
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