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Compounds capable of interfering with Aβ Aβ interaction through binding to nucleation sites can inhibit Aβ amyloidogenesis and Aβ-induced cytotoxicity.
Conversely, the incidence of compounds capable of interfering with detection in the red-shifted region (e.g, excitation around 550 nm and emission near 590 nm) diminished to below 0.01% [27].
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This compound is capable of interfering with microtubule dynamics and is believed to have potential carbonic anhydrase IX inhibiting activity.
These "dioxin-like compounds" (DLCs) are capable of interfering with embryonic development and eliciting acute and chronic effects on reproduction, immune function, and other essential processes [ 7, 8] with population-level consequences [ 9].
Exploiting chemistry to develop compounds capable of selective recognition of biomolecules or interfering with cellular processes is the essence of chemical biology. 1 One example of such biologically relevant targets are nucleic acid G-quadruplexes.
N. fruticans and O. stamineus extracts enabled the host to survive both antibiotic-sensitive and antibiotic-resistant S. aureus infection without interfering with bacterial viability, suggesting that these extracts possess compounds capable of targeting the host defense mechanism or attenuating bacterial virulence traits.
Furthermore, the development of models capable of distinguishing compounds capable of activating T-cells need to be developed.
We recently identified niclosamide, perhexiline, and rottlerin as compounds capable of rapidly inducing autophagy [43].
They identified two novel compounds capable of lowering blood glucose, but these compounds also paradoxically activated pck1 expression.
Four hit compounds capable of inhibiting >50% of the radioligand binding were examined further.
Antiviral research on HSV preliminarily focuses on compounds capable of targeting the viral polymerase.
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